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KMID : 0363219930310030337
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Korean Journal of Dermatology
1993 Volume.31 No. 3 p.337 ~ p.340
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The Keratolytic Effect of Several Enzymes and Irritants
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Abstract
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Background:
@EN Several keratolytic agents have been used in many dermatologic conditions such as callus, keratosis palmaris et plantaris, however the evaluation method of the effects of keratolytic agents has not been good enough in clinical use.
@ES Object:
@EN We have conducted an investigation to measure the effect of several keratolytic agents using an in vitro model.
@ES Method:
@EN We measured the degraded protein of keratin by the buriet method after adding enzymes such as trypsin, pepsin and papain, and irritants ; salicylic acid and sodium lauryl sulfate to the collected callus.
@ES Result:
@EN The order of the keratolytic effect of the enzymes was trypsin>pepsin>papain. It was difficult to detect the keratolytic effect of salicylic acid because of color hindrance and there was an increasing tendency of keratolytic effect of sodium
lauryl
sulfate, however it was prominent mainly at a high concentration.
@ES Conclusion:
@EN These results suggested that the potency of similar types of keratolytic enzymes such as pepsin, trypsin and papain can be possible. However it was not such a suitable model to check the potency of the keratolytic effect of salicylic acid and
the
concentration level may be an important factor for certain kinds of chemicals such as sodium lauryl sulfate. (Kor J Dermatol 1993 ; 31(3) : 337-340)
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